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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1773 | Afatinib Dimaleate | BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate | EGFR , HER , Autophagy |
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic act... | |||
T64075 | Afatinib oxalate | ||
Afatinib (BIBW 2992) oxalate is an irreversible, orally active bispecific inhibitor of the ErbB family (EGFR and HER2) that acts on EGFRwt (IC50: 0.5 nM), EGFRL858R (IC50: 0.4 nM), EGFRL858R/T790M ( IC50: 10 nM) and HER2... | |||
T2303 | (S)-Afatinib | BIBW2992 | EGFR , HER |
(S)-Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, EGFR (L858R), EGFR (L858R/T790M), HER2, and HER4, respectively. | |||
T10256 | Afatinib D6 | BIBW 2992 D6 | EGFR |
Afatinib D6 (BIBW 2992 D6) is a deuterium-labeled Afatinib. Afatinib is an irreversible EGFR family inhibitor. | |||
T72912 | (R)-Afatinib | (R)-BIBW 2992 | |
(R)-Afatinib ((R)-BIBW 2992), an isomer of Afatinib, is a potent, orally administered, irreversible inhibitor targeting the ErbB family (EGFR and HER2) with IC50 values of 0.5 nM for EGFR wt, 0.4 nM for EGFR L858R, 10 nM... | |||
T21312 | Afatinib | Afatinib free base,BIBW 2992 | EGFR , Autophagy |
Afatinib (BIBW 2992) is an irreversible inhibitor of EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M and HER2 with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM , respectively). |